Compile Data Set for Download or QSAR
maximum 50k data
Found 3875 of Enz. Inhib. data with enzyme = 'Monoglyceride lipase' and Substrate = 'to-be-curated'
TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM640384((S)-(2-Chloro-6-fluorophenyl)(3-(3,5-difluoropheny...)
Affinity DataIC50:  0.00200nMAssay Description:The assay consists of combining endogenously expressed MGL from HeLa cells with test compounds, adding [glycerol-1,3-3H]-oleyl glycerol, incubating f...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50582221(CHEMBL5090028 | US11708359, Example 60)
Affinity DataIC50:  0.00700nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581474((2s,4s)-2-(2-(3-(tert-Butyl)phenyl)-7-azaspiro[3.5...)
Affinity DataIC50:  0.0140nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609871((rac)-(2s,4s)-2-(6-(4-(tert-Butyl)phenyl)-3-azabic...)
Affinity DataIC50:  0.0190nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50582222(CHEMBL5074982 | US11708359, Example 71)
Affinity DataIC50:  0.0240nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581599((2r,4s)-2-(2-(5-(tert-Butyl)-2-methylphenyl)-7-aza...)
Affinity DataIC50:  0.0270nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609880((rac)-(2s,4s)-2-(6-(4-(1-Methylcyclopropyl)phenyl)...)
Affinity DataIC50:  0.0340nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581624((rac)-(2s,4s)-2-(2-(4-(Trifluoromethyl)phenyl)-8-a...)
Affinity DataIC50:  0.0390nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581678((2s,4S)-N-((1s,3S)-3-(4-Isopropylphenyl)cyclobutyl...)
Affinity DataIC50:  0.0400nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581534((2s,4s)-2-[2-(3-Isopropylphenyl)-7-azaspiro[3.5]no...)
Affinity DataIC50:  0.0410nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581597((2s,4s)-2-[2-(2,4-Dimethylphenyl)-7-azaspiro[3.5]n...)
Affinity DataIC50:  0.0480nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609878((rac)-(2s,4s)-2-(6-(3-Chloro-4-methylphenyl)-3- az...)
Affinity DataIC50:  0.0750nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581596((2r,4s)-2-(2-(3-(tert-Butyl)phenyl)-7-azaspiro[3.5...)
Affinity DataIC50:  0.0820nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581635((rac)-(2s,4s)-2-(6-(3-(tert-Butyl)phenyl)-2-azaspi...)
Affinity DataIC50:  0.0860nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581518((2s,4s)-2-[2-(3-Cyclopropylphenyl)-7-azaspiro[3.5]...)
Affinity DataIC50:  0.0880nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581594((2s,4s)-2-[2-[3-(Trifluoromethoxy)phenyl]-7-azaspi...)
Affinity DataIC50:  0.0940nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581601((2r,4s)-2-(2-(6-(tert-Butyl)pyridin-2-yl)-7-azaspi...)
Affinity DataIC50:  0.0950nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581650((2s,4s)-2-(6-(3-(tert-Butyl)phenyl)-2-azaspiro[3.3...)
Affinity DataIC50:  0.0970nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581631((2s,4R*)-2-((S*)-6-(4-(Trifluoromethyl)phenyl)-2-a...)
Affinity DataIC50:  0.100nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM630876((7-((3,6-Dimethyl-5-(trifluoromethyl)pyridin-2-yl)...)
Affinity DataIC50:  0.100nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581648((rac)-(2s,4s)-2-(6-(4-Isopropylphenyl)-2-azaspiro[...)
Affinity DataIC50:  0.100nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581642((rac)-(2s,4s)-2-(2-(3-(tert-Butyl)phenyl)-8-azaspi...)
Affinity DataIC50:  0.100nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581643((rac)-(2s,4s)-2-(2-(4-(tert-Butyl)phenyl)-8-azaspi...)
Affinity DataIC50:  0.110nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581595((2s,4s)-2-[2-(2,3-Dimethylphenyl)-7-azaspiro[3.5]n...)
Affinity DataIC50:  0.110nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581634((rac)-(2s,4s)-2-(6-(4-(tert-Butyl)phenyl)-2-azaspi...)
Affinity DataIC50:  0.110nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM597443((4-Fluoropyrazolo[1,5-a]pyridin-3-yl)((5R,9S)-2-me...)
Affinity DataIC50:  0.140nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581646((rac)-(2s,4s)-2-(6-(3-Isopropylphenyl)-2-azaspiro[...)
Affinity DataIC50:  0.170nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM597214((4-Bromoquinolin-6-yl)((5R,9S)-3-(3,5-difluorophen...)
Affinity DataIC50:  0.180nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581668((2s,4S)-N-((1s,3S)-3-(4-(tert-Butyl)phenyl)cyclobu...)
Affinity DataIC50:  0.200nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM626988((2s,4R*)-2-((2S*,4R*)-4-(4-(tert-Butyl)phenyl)-2-m...)
Affinity DataIC50:  0.200nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM597927(US11608347, Example 55 | [(7R,9aR)-7-(3-chloro-4- ...)
Affinity DataIC50:  0.200nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM626965((racemic)-(2s,4S)-2-((3R,4R)-4-(4-(tert-Butyl)phen...)
Affinity DataIC50:  0.200nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM630668(((1s,3s)-3-Hydroxy-3-methylcyclobutyl)(7-(2-methyl...)
Affinity DataIC50:  0.200nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM626948((2s,4s)-2-(4-(4-(tert-Butyl)phenyl)piperidine-1-ca...)
Affinity DataIC50:  0.200nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581658((2s,4s)-2-(6-(3-Cyclobutylphenyl)-2-azaspiro[3.3]h...)
Affinity DataIC50:  0.210nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609885((rac)-(2s,4s)-2-(6-(4-Isopropylphenyl)-3-azabicycl...)
Affinity DataIC50:  0.210nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM630869((7-((6-Ethoxy-5-(trifluoromethyl)pyridin-2-yl)oxy)...)
Affinity DataIC50:  0.220nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581625((rac)-(2s,4s)-8-Methyl-2-(2-(4-(trifluoromethyl)ph...)
Affinity DataIC50:  0.230nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM597179(((5R,9S)-3-(3,5-Difluorophenyl)-2-methyl-4,5,6,7,8...)
Affinity DataIC50:  0.240nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581697((2s,4S)-N-((1s,3S)-3-(4-Cyclopropyl-3-methylphenyl...)
Affinity DataIC50:  0.25nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609884((rac)-(2s,4s)-2-(6-(3-Isopropylphenyl)-3-azabicycl...)
Affinity DataIC50:  0.25nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581630((2s,4s)-2-((R*)-6-(4-(Trifluoromethyl)phenyl)-2-az...)
Affinity DataIC50:  0.25nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609870((rac)-(2r,4s)-2-(6-(3-(tert-Butyl)phenyl)-3-azabic...)
Affinity DataIC50:  0.25nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581706((2s,4S)-N-Methyl-N-((1s,3S)-3-(4-(1-methylcyclopro...)
Affinity DataIC50:  0.25nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM474403(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(phenylsulfony...)
Affinity DataIC50:  0.259nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM597346((1-Methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)((5R,9S)-2...)
Affinity DataIC50:  0.260nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM596512((2-Chloro-3-methoxyphenyl)((5R,9S)-2-methyl-3-phen...)
Affinity DataIC50:  0.260nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM597132(US11597728, Example 18 | racemic-(1-Methyl-1H-indo...)
Affinity DataIC50:  0.260nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581652((2s,4s)-2-(6-(3-Isopropylphenyl)-2-azaspiro[3.3]he...)
Affinity DataIC50:  0.280nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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TargetMonoglyceride lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM581645((2s,4s)-2-(2-(3-(tert-Butyl)phenyl)-6-azaspiro[3.4...)
Affinity DataIC50:  0.280nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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